|
T3206 |
NKL 22
|
Histone Deacetylase Inhibitor IV,PAOA |
HDAC
|
|
NKL 22 (Histone Deacetylase Inhibitor IV) is an effective Histone Deacetylase Inhibitor. |
|
T1819 |
Nexturastat A
|
|
HDAC
|
|
Nexturastat A is an effective and specific HDAC6 inhibitor (IC50: 5 nM). Its selectivity is >190-fold than other HDACs. |
|
T6327 |
Tubacin
|
|
Virus Protease
,
HDAC
|
|
Tubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM, approximately 350-fold selectivity over HDAC1. |
|
T7664 |
Pyroxamide
|
|
Apoptosis
,
HDAC
|
|
Pyroxamide is an histone deacetylases (HDACs) inhibitor with antineoplastic properties ( HDAC1;IC50: 0.1-0.2 μM). |
|
T9745 |
Elevenostat
|
|
HDAC
|
|
Elevenostat is an HDAC11-selective inhibitor with an IC50 value of 0.235 µM. |
|
T16129 |
MPI_5a
|
|
HDAC
|
|
MPI_5a is an effective and selective inhibitor of HDAC6 (IC50=36 nM). MPI_5a weakly inhibits other HDAC isoforms and it also inhibits acyl-tubulin accumulation in cells (IC50: 210 nM). |
|
T5830 |
SKLB-23bb
|
|
HDAC
|
|
SKLB-23bb is an orally bioavailable HDAC6-selective inhibitor and also has microtubule-disrupting ability. |
|
T5631 |
SIS17
|
|
HDAC
|
|
SIS17 is a potent and selective HDAC 11 inhibitor with an IC50 value of 0.83 μM. SIS17, is active in cells and inhibited the demyristoylation of a known HDAC11 substrate, serine hydroxymethyl transferase 2, without inhib... |
|
T5332 |
TH34
|
|
HDAC
|
|
TH34 is an HDAC6/8/10 inhibitor (IC50s: 4.6/1.9/7.7 μM). It shows high selectivity over HDAC1/2/3. |
|
T3205 |
UF010
|
|
HDAC
|
|
UF010 is a potent and selective HADC inhibitor with IC50 ~0.06 μM, 0.1 μM, 0.5 μM and 1.5 μM for HDACs 3, 2, 1 and 8, respectively. |
|
T1857 |
TMP269
|
|
HDAC
|
|
TMP269 is an effective, specific class IIa HDAC inhibitor for HDAC4 (IC50: 157 nM), HDAC5 (IC50: 97 nM), HDAC7 (IC50: 43 nM), and HDAC9 (IC50: 23 nM), respectively. |
|
T16962 |
SW-100
|
|
HDAC
|
|
SW-100 is a selective histone deacetylase 6 inhibitor (IC50: 2.3 nM). It also shows at least 1000-fold selectivity for HDAC6 relative to all other HDAC isozymes. SW-100 displays an obviously improved ability to cross the... |
|
TQ0074 |
ACY-775
|
|
HDAC
|
|
ACY-775 is an effective and specific inhibitor of HDAC6 (IC50: 7.5 nM). |
|
T10602L |
BRD 4354
|
|
HDAC
|
|
BRD 4354 is an inhibitor of HDAC5 and HDAC9. For HDAC5 and HDAC9, the IC50s values are 0.85 and 1.88 μM, respectively. |
|
T8508 |
HDAC-IN-3
|
GSK3117391A |
HDAC
|
|
HDAC-IN-3 (GSK3117391A) is a potent histone deacetylase (HDAC) inhibitor, and treatment chronic inflammatory disorders. |
|
T21715 |
BRD6688
|
|
HDAC
|
|
BRD6688 is a selective HDAC2 inhibitor that acts by enhancing the learning and memory processes |
|
T2023 |
MC1568
|
|
HDAC
|
|
MC1568 is a specific HDAC inhibitor for maize HD1-A (IC50: 100 nM, in a cell-free assay). It is 34-fold more selective for HD1-A than HD1-B. |
|
T7082 |
HDAC8-IN-1
|
|
HDAC
|
|
MDK-7933 (HDAC8-IN-1) is a HDAC8 inhibitor with an IC50 of 27.2 nM in cancer cell lines. MDK-7933 shows antiproliferative effects toward several human lung cancer cell lines (A549, H1299, and CL1-5). HDAC8-IN-1 exhibits ... |
|
T2430 |
HPOB
|
|
Apoptosis
,
HDAC
|
|
|
|
T7385 |
WT-161
|
|
Apoptosis
,
HDAC
|
|
WT161 is a potent and selective inhibitor of HDAC6 (IC50:0.40 nM). |
|
T3358 |
ITSA-1
|
ITSA1 |
HDAC
|
|
ITSA-1 is membrane permeable and specifically suppresses TSA inhibition of HDAC (histone deacetylase), but shows no activity towards other HDAC inhibitors. |
|
T6061 |
LMK-235
|
LMK235 |
HDAC
|
|
LMK-235 is a potent HDAC inhibitor, and is used in cancer research. |
|
T5347 |
CXD101
|
CXD-101 |
HDAC
|
|
CXD101 is a novel class I-selective HDACi (HDAC1 (IC50 : 63nM), HDAC2 (IC50 :570nM), HDAC3 (IC50 :550nM)). CXD101(CXD-101) has no activity against HDAC class II |
|
T2294 |
BG45
|
|
Apoptosis
,
HDAC
|
|
BG45 is an HDAC I type inhibitor with IC50 of 289 nM, 2.0 μM, 2.2 μM and >20 μM for HDAC3/1/2/6 in cell-free assays, respectively. |
|
T1762 |
RGFP966
|
RGFP 966 |
HDAC
|
|
RGFP966 is an HDAC3 inhibitor (IC50: 0.08 μM) and does not affect other HDACs at concentrations up to 15 µM. |
|
T4389 |
SR-4370
|
SR 4370 |
HDAC
|
|
SR-4370 is an HDAC inhibitor. SR- 4370 exhibited IC50 values of 0.5 μM, 0.1 μM and 0.06 μM towards HDAC1, HDAC2 and HDAC3, resp. |
|
T3509 |
ACY-738
|
ACY 738 |
HDAC
|
|
ACY-738 demonstrates inhibitory activity against recombinant HDAC6 (IC50: 1.7 nM), with respective average selectivity over class I HDACs being 100-fold. |
|
T0867 |
Bufexamac
|
Bufexamic acid |
COX
,
HDAC
|
|
Bufexamac (Bufexamic acid) is a COX inhibitor for IFN-α release with anti-inflammatory, analgesic, and antipyretic action. |
|
T16729 |
Remetinostat
|
SHP-141 |
HDAC
|
|
Remetinostat (SHP-141), a hydroxamic acid-based inhibitor of histone deacetylase enzymes, is currently being developed for the treatment of cutaneous T-cell lymphoma. |
|
T6055 |
Quisinostat
|
JNJ-26481585 |
Apoptosis
,
HDAC
,
Autophagy
|
|
Quisinostat (JNJ-26481585) (JNJ-26481585) is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM, modest potent to HDACs 2, 4, 10, and 11; greater than 30-fold selectivity against... |
|
T10777 |
CG347B
|
|
HDAC
|
|
CG347B is a selective inhibitor of HDAC6. |
|
T2157 |
M344
|
MS 344,Histone Deacetylase Inhibitor III |
HDAC
|
|
M344 (Histone Deacetylase Inhibitor III) is a potent HDAC inhibitor with IC50 of 100 nM and able to induce cell differentiation. |
|
T1966 |
Tubastatin A
|
Tubastatin A BASE |
Apoptosis
,
HDAC
,
Autophagy
|
|
Tubastatin A (Tubastatin A BASE) is an effective and specific HDAC6 inhibitor (IC50: 15 nM, in a cell-free assay). Its selectivity is 1000-fold against all the other isozymes except HDAC8. |
|
T1890 |
Pracinostat
|
SB939 |
Apoptosis
,
HDAC
|
|
Pracinostat (SB939) is a novel HDAC inhibitor with improved in vivo properties compared to other HDAC inhibitors currently in Clinicalal trials, allowing oral dosing. Data demonstrate that Pracinostat is a potent and eff... |
|
T10255 |
AES-135
|
|
HDAC
|
|
AES-135 is a potent HDAC inhibitor, inhibits HDAC3, HDAC6, HDAC11 (IC50s: 654, 190, and 636 nM) with anti-tumor activity. |
|
T9148 |
KA2507
|
|
HDAC
|
|
KA2507 is a potent and selective HDAC6 inibitor with an IC50 of 2.5nM. |
|
T9041 |
AES-350
|
|
Apoptosis
,
HDAC
|
|
AES-350 is a potent and orally active HDAC6 inhibitor(IC50 and a Ki of 0.0244 μM and 0.035 μM, respectively). It is also against HDAC-3, -8, and -11 in an enzymatic activity assay with IC50 values of 0.187 μM, 0.245 μM, ... |
|
T9963 |
MPT0B390
|
|
HDAC
|
|
MPT0B390 is an inhibitor of HDAC and a TIMP3 inducer inhibiting tumor growth, metastasis, and angiogenesis. |
|
T10603 |
BRD-6929
|
|
HIV Protease
,
HDAC
|
|
BRD-6929 is a selective, brain-penetrant HDAC1 and HDAC2 inhibitor (IC50: 1 and 8 nM). BRD-6929 (Cpd-60) shows high-affinity to HDAC1 and HDAC2 (Kis: 0.2 and 1.5 nM) [2]. BRD-6929 potentiates the efficacy of gnidimacrin... |
|
T6695 |
Tasquinimod
|
ABR-215050 |
HDAC
|
|
Tasquinimod (ABR-215050) is a quinoline-3-carboxamide linomide analog with antiangiogenic and potential antineoplastic activities. Tasquinimod has been shown to decrease blood vessel density but the exact mechanism of ac... |
|
T2489 |
Ricolinostat
|
ACY-1215,Rocilinostat |
Apoptosis
,
HDAC
|
|
Ricolinostat (Rocilinostat) is an orally bioavailable, specific inhibitor of histone deacetylase 6 (HDAC6) with potential antineoplastic activity. |
|
T3204 |
BML-210
|
CAY10433 |
Apoptosis
,
HDAC
|
|
BML-210 (CAY10433) is a new-type HDAC inhibitor. |
|
T6678 |
Splitomicin
|
1-Naphthalenepropanoic Acid |
Sirtuin
,
HDAC
|
|
Splitomicin (1-Naphthalenepropanoic Acid) (IC50 of 60 μM), a specific inhibitor of NAD(+)-dependent histone deacetylase Sir2p, displays a high activity in a cell-based assay. |
|
T3193 |
Pimelic diphenylamide 106
|
Histone Deacetylase Inhibitor VII,TC-H 106,RGFA-8 |
HDAC
|
|
Pimelic diphenylamide 106 (RGFA-8) is a slow, tight-binding inhibitor of class I HDAC (with IC50 values of 150 nM , 760 nM and 370 nM for HDAC 1, 2, and 3, respectively), showing no activity against class II HDACs. |
|
T13996 |
1-Naphthohydroxamic acid
|
|
HDAC
|
|
1-Naphthohydroxamic acid (Compound 2) is a potent and selective HDAC8 inhibitor with an IC50 of 14 μM, and it is more selectively for HDAC8 than class I HDAC1 and class II HDAC6 (IC50 >100 μM). 1-Naphthohydroxamic acid d... |
|
T6421 |
BRD73954
|
|
HDAC
|
|
BRD73954, an effective and specific HDAC inhibitor, which is with IC50 of 36 nM and 120 nM for HDAC6 and HDAC8, respectively. |
|
T6980 |
Scriptaid
|
GCK1026,Scriptide |
Apoptosis
,
Influenza Virus
,
HDAC
,
Autophagy
|
|
Scriptaid (GCK1026) is an inhibitor of HDAC, and has a greater effect on acetylated H4 than H3. |
|
T6639 |
RG2833
|
RGFP109 |
HDAC
|
|
RG2833 (RGFP109) (RGFP109), a brain-penetrant HDAC inhibitor, is with IC50 of 60 nM and 50 nM for HDAC1 and HDAC3, respectively. |
|
T3108 |
CUDC-101
|
CUDC 101,CUDC101 |
EGFR
,
HER
,
HDAC
|
|
CUDC-101 is a potent inhibitor of HDAC, EGFR and HER2 with IC50s of 4.4, 2.4 and 15.7 nM, respectively. |
|
T3983 |
TMP195
|
TFMO 2,TMP 195 |
HDAC
|
|
TMP195 (TFMO 2) is a selective class IIa histone deacetylase (HDAC) inhibitor. |
